small synthetic agonist compound 48 Search Results


wnt agonist1  (Selleck Chemicals)
93
Selleck Chemicals wnt agonist1
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
Wnt Agonist1, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/Wnt+agonist+1/pmc08642992-82-18-21
Average 93 stars, based on 1 article reviews
wnt agonist1 - by Bioz Stars, 2026-10
93/100 stars
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y1 agonist  (Bachem)
90
Bachem y1 agonist
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
Y1 Agonist, supplied by Bachem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/y1+agonist/us10143727-194-13-17
Average 90 stars, based on 1 article reviews
y1 agonist - by Bioz Stars, 2026-10
90/100 stars
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chrm4 arrestin agonist  (DiscoverX corporation)
90
DiscoverX corporation chrm4 arrestin agonist
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
Chrm4 Arrestin Agonist, supplied by DiscoverX corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/pathhunter+cell+lines+expressing+the+tagged+chrm1/pmc06182605__213_2018_4980_MOESM1_ESM-30-17-42
Average 90 stars, based on 1 article reviews
chrm4 arrestin agonist - by Bioz Stars, 2026-10
90/100 stars
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agonist  (Zoetis)
86
Zoetis agonist
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
Agonist, supplied by Zoetis, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/agonist/pmc12586328-122-6-23
Average 86 stars, based on 1 article reviews
agonist - by Bioz Stars, 2026-10
86/100 stars
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β-ala 8 )-neurokinin a(4–10  (Bachem)
90
Bachem β-ala 8 )-neurokinin a(4–10
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
β Ala 8 ) Neurokinin A(4–10, supplied by Bachem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/nle10++nka/pmc06674731-113-15-40
Average 90 stars, based on 1 article reviews
β-ala 8 )-neurokinin a(4–10 - by Bioz Stars, 2026-10
90/100 stars
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c43 agonist  (Merck KGaA)
90
Merck KGaA c43 agonist
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
C43 Agonist, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/c43+agonist/pmc12081931-116-1-3
Average 90 stars, based on 1 article reviews
c43 agonist - by Bioz Stars, 2026-10
90/100 stars
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agonists  (Novartis)
86
Novartis agonists
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
Agonists, supplied by Novartis, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/agonists/pmc08758203-21-8-2
Average 86 stars, based on 1 article reviews
agonists - by Bioz Stars, 2026-10
86/100 stars
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axokinetm  (Regeneron inc)
90
Regeneron inc axokinetm
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
Axokinetm, supplied by Regeneron inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/axokinetm/us08507681-210-130-103
Average 90 stars, based on 1 article reviews
axokinetm - by Bioz Stars, 2026-10
90/100 stars
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thrx-199874 (bzi; 4-(2-oxo-2,3-dihydro-benzimidazol-1-yl)-1,4′-bipi- peridinyl-1′-carboxylic acid ethyl ester)  (Theravance inc)
90
Theravance inc thrx-199874 (bzi; 4-(2-oxo-2,3-dihydro-benzimidazol-1-yl)-1,4′-bipi- peridinyl-1′-carboxylic acid ethyl ester)
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
Thrx 199874 (Bzi; 4 (2 Oxo 2,3 Dihydro Benzimidazol 1 Yl) 1,4′ Bipi Peridinyl 1′ Carboxylic Acid Ethyl Ester), supplied by Theravance inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/thrx+199874++bzi++4++2+oxo+2+3+dihydro+benzimidazol+1+yl++1+4++bipi++peridinyl+1++carboxylic+acid+ethyl+ester+/pm29093194-184-13-24
Average 90 stars, based on 1 article reviews
thrx-199874 (bzi; 4-(2-oxo-2,3-dihydro-benzimidazol-1-yl)-1,4′-bipi- peridinyl-1′-carboxylic acid ethyl ester) - by Bioz Stars, 2026-10
90/100 stars
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agonist  (Eisai Inc)
86
Eisai Inc agonist
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
Agonist, supplied by Eisai Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/agonist/pmc13269242-32-3-17
Average 86 stars, based on 1 article reviews
agonist - by Bioz Stars, 2026-10
86/100 stars
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5-ht1a agonists  (Matos labs)
90
Matos labs 5-ht1a agonists
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
5 Ht1a Agonists, supplied by Matos labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/5+ht+neurotransmitter/pm36133803-246-8-20
Average 90 stars, based on 1 article reviews
5-ht1a agonists - by Bioz Stars, 2026-10
90/100 stars
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am-9747  (CEREP Inc)
90
CEREP Inc am-9747
CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt <t>agonist1</t> and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection
Am 9747, supplied by CEREP Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+synthetic+agonist+compound+48/am+9747/pmc11956014__jm4c03101_si_001-137-27-18
Average 90 stars, based on 1 article reviews
am-9747 - by Bioz Stars, 2026-10
90/100 stars
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CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt agonist1 and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection

Journal: Molecular Cancer

Article Title: A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression

doi: 10.1186/s12943-021-01457-w

Figure Lengend Snippet: CircAXIN1 activates the Wnt/β-catenin signaling pathway. a-b CircAXIN1 and AXIN1-295aa activate Wnt/β-catenin-dependent transcription. a Topflash/Fopflash assays were performed in 293 T and AGS cells with circAXIN1 transfection. b Topflash/Fopflash assays were performed in 293 T and AGS cells with linear-295aa transfection. c Topflash/Fopflash assays were performed in 293 T cells with individual circAXIN1 siRNA transfection. d Inhibition of circAXIN1 causes downregulation of β-catenin in both the cytoplasm and nucleus. Expression of β-catenin in the cytoplasm and nucleus with individual circAXIN1 siRNA transfection. e CircAXIN1 overexpression enhances β-catenin nuclear translocation and circAXIN1 siRNA inhibits β-catenin nuclear translocation. Immunofluorescence localization of β-catenin was detected with circAXIN1 or circAXIN1 siRNA transfection. Wnt agonist1 and XAV939 (a Wnt/β-catenin signaling inhibitor) served as positive controls. f CircAXIN1 overexpression activates the downstream gene expression of the Wnt/β-catenin pathway. g Individual circAXIN1 siRNA transfection leads to the reduced expression of Wnt/β-catenin pathway downstream genes. h The mRNA levels of c-Myc, c-Jun, CD44, Met, cyclinD1, and VEGF decrease with each circAXIN1 siRNA transfection. i More β-catenin binds to the TCF-dependent promoter of Wnt/β-catenin downstream genes with overexpression of circAXIN1. A ChIP assay was performed using anti-β-catenin to detect the binding of β-catenin to the promoters of c-Jun , c-Myc , and CD44 . C-Jun1/2 means region1 or 2 of the c-Jun promoter. j Linear AXIN1-295aa rescues the inhibitory effect of circAXIN1 siRNA on Topflash activity. Topflash/Fopflash assays were performed with circAXIN1 siRNA transfection or co-transfection of circAXIN1 and linear-295aa. k Linear AXIN1-295aa elevates the downregulation of genes downstream of the Wnt/β-catenin pathway caused by circAXIN1 siRNA transfection

Article Snippet: Cells were inoculated in 35-mm petri dishes (NEST) and transfected with OV-circAXIN1 or circAXIN1 si1 for 48 h. Wnt agonist1 (S8178, Selleckchem) and XAV-939 (S1180, Selleckchem) (10 and 1 μM, respectively) were used as positive controls.

Techniques: Transfection, Inhibition, Expressing, Over Expression, Translocation Assay, Immunofluorescence, Gene Expression, Binding Assay, Activity Assay, Cotransfection